![]() Of note, this upward trend has continued despite noted decreases in opioid prescribing.Īlthough there is evidence of a declining use of prescription opioids over time ( Guy et al., 2017), trends in use patterns have not been examined among patients who develop OUD or opioid-related overdose (OD) ( Madras 2017 Dowell et al., 2016 Soelberg et al., 2017). Both US survey and administrative claims data have shown a consistent upward trend in the prevalence of OUD, at the magnitude of a 3-fold increase from 2003 to 2013 ( Dufour et al., 2014 Kirson et al., 2015). National survey data suggest that 1.9 million adults (0.8%) had OUD in 2015, with a higher prevalence (2.1%) observed among adults who use prescription opioids ( Han et al., 2017). ![]() The Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) characterizes OUD as problematic use of opioids leading to significant impairment or distress characterized by the presence of at least 2 of 11 symptoms in a 12-month period ( Hasin et al., 2013). Opioid use disorder (OUD) is the main contributor to opioid-related morbidity and mortality in the United States (U.S.) ( Rudd et al., 2016). ![]() Further investigations are warranted to understand how prescribed and anticonvulsants contribute to the development of OUD/OD. Between 20, the proportion of patients with incident OUD/OD who received anticonvulsant adjuvant analgesics in the year before diagnosis increased (from 23.4% to 34.3% ) whereas the proportion receiving high-dose prescriptions opioids decreased (from 45.5% to 34.8% [P-trend =DiscussionIn US commercially insured patients newly diagnosed with OUD/OD, receipt of high-dose opioid prescriptions preceding the diagnosis decreased over time, paralleled by increased use of anticonvulsants commonly prescribed for pain conditions. Trends were examined in the overall sample and by 3 age groups, including youths (≤18 years), adults (19-64 years), and older adults (≥65 years).ResultsThe incidence of diagnosed OUD or OD increased more than 3-fold from 4.99 to 23.81 per 10,000 persons from 2006 to 2016, with the highest increase (14.18-fold) seen in older adults, followed by adults (3.53-fold), and youths (0.16-fold). BackgroundWith increasing efforts to scrutinize and reduce opioid prescribing, limited data exist on the recent trend in receipt of prescription pain medications before diagnosis of opioid use disorder (OUD) or opioid-related overdose (OD).MethodsUsing 2005-2016 Truven MarketScan Commercial Claims databases, we assessed trends in annual 1) incidence of OUD or OD and 2) prevalence of receipt of prescription opioids or four commonly-prescribed adjuvant analgesics among patients newly diagnosed with OUD/OD.
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